Entresto

The active ingredient in Entresto is a combination of valsartan, a nonpeptide angiotensin II receptor antagonist, and sacubitril, an inhibitor of neprilysin (neutral endopeptidase), an endogenous peptidase enzyme that degrades neurohormones such as bradykinin, substance P and natriuretic peptides. Inhibition of neprilysin by sacubitril increases the amount of natriuretic peptides in your body, producing vasodilation and decreasing fluid in the blood vessels.

The active ingredient in Entresto is a combination of valsartan, a nonpeptide angiotensin II receptor antagonist, and sacubitril, an inhibitor of neprilysin (neutral endopeptidase), an endogenous peptidase enzyme that degrades neurohormones such as bradykinin, substance P and natriuretic peptides.

Inhibition of neprilysin by sacubitril increases the amount of natriuretic peptides in your body, producing vasodilation and decreasing fluid in the blood vessels.

Inhibition of neprilysin by sacubitril increases the amount of natriuretic peptides in your body, producing vasodilation and decreasing fluid in the blood vessels.

The production of these hormones results in:

Vasodilation – which decreases fluid retention and swelling in your body

Decreases blood pressure, especially systolic pressure (the higher number on your blood pressure reading)

Decreases heart rate

Entresto medicine is good for heart medication.

As with any medicine, Entresto has side effects. Serious side effects that may require a patient to stop taking the drug include the following:

Severe skin rash or itching (hives), swelling of your face, lips, tongue, or throat

Rapid weight gain (3 pounds in one week)

If you have hives or swelling of your lips, face, tongue, or throat; if you have difficulty breathing; or if you get new symptoms such as dizziness and fainting when you start taking this medication – take it back to the doctor who prescribed it for you immediately.